The goal of this randomized controlled trial is to test the effectiveness of a resilience intervention and an adherence intervention in improving health-related quality of life (HRQoL) among perinatally infected HIV positive children and their HIV positive mothers in China. The main questions it aims to answer are: 1. Whether baseline resilience and treatment adherence are associated with the HRQoL; 2. Whether the resilience intervention will improve the mediators associated with intervention sessions, such as positive coping and social support, the proximal outcome of resilience factors, the distal outcome of HRQoL, and dyadic level outcomes such as dyadic coping; 3. Whether the adherence intervention will improve the mediators associated with intervention sessions, such as adherence information and behavioral skills, the proximal outcome of self-reported adherence, the distal outcome of HRQoL, and dyadic level outcomes such as dyadic coping; 4. Whether the enhanced mediators (e.g., positive coping and social support) associated with the resilience-intervention sessions at the end of the intervention will transmit the effect of the resilience intervention on the increases in resilience factors during follow-ups; 5. Whether the improved mediators (e.g., adherence information and behavioral skills) associated with the adherence-intervention sessions at the completion of the intervention will transmit the effect of the adherence intervention on the increases in adherence in follow-ups. Participating mother-child dyads in the two intervention arms will receive two sessions of dyadic intervention. Researchers will compare the above-described outcomes between participants in the two intervention arms and the control arm (treatment as usual) to see the effectiveness of the interventions.
Age range
10 Years – 17 Years
Sex
ALL
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Change of health-related quality of life (HRQoL)
Timeframe: Baseline, 2 weeks (immediately after the last session of intervention), 1 month and 3 months
Change of depressive symptoms
Timeframe: Baseline, 2 weeks (immediately after the last session of intervention), 1 month and 3 months
Change of anxiety symptoms
Timeframe: Baseline, 2 weeks (immediately after the last session of intervention), 1 month and 3 months
Change of resilience factors
Timeframe: Baseline, 2 weeks (immediately after the last session of intervention), 1 month and 3 months
Change of HAART adherence
Timeframe: Baseline, 2 weeks (immediately after the last session of intervention), 1 month and 3 months
Change of mediators in the resilience intervention: Perceived stigma
Timeframe: Baseline, 2 weeks (immediately after the last session of intervention)
Change of mediators in the resilience intervention: Emotional regulation
Timeframe: Baseline, 2 weeks (immediately after the last session of intervention)
Change of mediators in the resilience intervention: Positive coping
Timeframe: Baseline, 2 weeks (immediately after the last session of intervention)
Change of mediators in the resilience intervention: Social support
Timeframe: Baseline, 2 weeks (immediately after the last session of intervention)
Change of mediators in the resilience intervention: Self-efficacy
Timeframe: Baseline, 2 weeks (immediately after the last session of intervention)
Change of mediators in the adherence intervention: Adherence information, motivation, and behavioral skills
Timeframe: Baseline, 2 weeks (immediately after the last session of intervention)
Change of mediators in the adherence intervention: Illness perception
Timeframe: Baseline, 2 weeks (immediately after the last session of intervention)
Change of mediators in the adherence intervention: Adherence efficacy
Timeframe: Baseline, 2 weeks (immediately after the last session of intervention)
Change of mediators in the adherence intervention: Children's medication-taking responsibility
Timeframe: Baseline, 2 weeks (immediately after the last session of intervention)