Predictors of Post-alteplase Hemorrhagic Transformation of Brain Infarction

Inclusion Criteria: * The investigators enrolled individuals of both genders, aged between 18 and 75, who presented with acute first-ever ischemic stroke and were eligible for thrombolysis. Exclusion Criteria: * The investigators excluded patients who had not been followed up on for 90 days after enrollment, * Those with alteplase contraindications or did not receive the total dose of alteplase due to any reason were excluded * The investigators excluded patients with a known history of persistent or recurrent CNS pathology (e.g., epilepsy, meningioma, multiple sclerosis, history of head trauma with a residual neurological deficit). * The investigators excluded patients who had recurrent ischemic stroke diagnosed by appropriate clinical history and/or MRI brain findings. * The investigators excluded patients with symptoms of major organ failure, active malignancies, or an acute myocardial infarction within the previous six weeks. * The investigators also excluded pregnant and lactating patients with stroke due to venous thrombosis and stroke following cardiac arrest