Faecal Microbiota Transplantation Against Chronic Diarrhea in Patients With Systemic Sclerosis

Inclusion Criteria: * Participants \> 18 years * Fulfilling and previously diagnosed with SSc according to the 2013 American College of Rheumatology/European League against rheumatisms SSs classification criteria\[23\] by rheumatologist or dermatologist. * Chronic diarrea is defined as loose or watery stools, three or more times a day, a minimum of 50% of the days within the last four weeks. Exclusion Criteria: * Inability to understand Danish spoken or written and/or Trial procedures. * Known or anticipated pregnancy (excluded by male sex, postmenopausal women, or otherwise negative U-HCG) * Previous treatment with FMT * Treatment with antibiotics within the past 6 weeks * Changes in morphine treatment within the past 4 weeks * Ongoing infection with Clostridioides difficile (negative PCR test) * Known serious gastrointestinal disease or GI infection (diagnosed with e.g. inflammatory bowel disease and/or gastrointestinal cancer) * Dysregulated thyroid disease (TSH) blood sample from previous consultations maximum 6 months old from * Known intestinal stricture * Planned MR scan within the study period * Pacemaker/ICD * Previous abdominal surgery (minor surgical procedures ex. appendectomy is allowed) * Changes in medicine that affect the GI tract within the past four weeks. * Known Severe end-organ disease * Lung disease with forced vital capacity(FVC)\<50% and/or diffusing lung capacity for carbon monoxide (DLCO) \<40% * Severe heart failure with ejection fraction \<…