Metabolic Availability in Older and Younger Men (NCT06332651) | Clinical Trial Compass
CompletedNot Applicable
Metabolic Availability in Older and Younger Men
Netherlands28 participantsStarted 2024-02-19
Plain-language summary
The main goal of this study is to determine the metabolic availability of methionine in black beans, lysine in sorghum and lysine in milk using the indicator amino acid oxidation method both in older and in younger men.
Who can participate
Age range20 Years – 80 Years
SexMALE
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Inclusion Criteria:
Gender: Male Age: 20-35 years or 65-80 years Body Mass Index (BMI): 18.5 - 30.0 kg/m2 Healthy as assessed with a questionnaire Regular and normal eating habits as assessed with a Food Frequency Questionnaire (FFQ) Willing to comply with study procedures and use of data Having given written informed consent
Exclusion Criteria:
Chronic disease, for example:
* Diabetes mellitus / being treated for high blood glucose
* Severe cardiovascular disease (exception: hypertension)
* Hepatic disease (e.g. hepatitis)
* Renal disease
* Cancer
* Bowel disease (e.g. inflammatory bowel disease, ulcers, bleeding)
* Pancreatitis
History of medical or surgical events that may affect GI function, and the study outcomes or disease risk for participants, for example:
* Bariatric surgery
* Gastrointestinal tract surgery
* Digestive tract disorder
* Chewing problems
* History of deep venous thrombosis without anti-coagulation medication
Medicine use that interferes with, protein metabolism, GI function and the study outcomes, for example:
* Glucose lowering drugs
* Proton pump inhibitors
* Laxatives
Habits that interfere with the study outcomes:
* Protein supplement use (current use or less than 2 weeks past use)
* Smoking
* Drug use
* Alcohol consumption \>21 units/week and/or \>4/day
* Following a weight-loss diet, medically prescribed diet or other diet with a low calorie intake or an unbalanced nutrient intake like a vegan or very low carbohydrate diet
* Moderate to …
What they're measuring
1
Metabolic availability of methionine in black beans and lysine in milk and sorghum measured with the indicator amino acid oxidation method.
Timeframe: 1 measurement to be calculated from repeated measurements on several test days separated by 1 week