Collagen for Treatment of Musculoskeletal Injuries

Inclusion criteria: For ACL reconstruction groups: * Type of damage (rupture of the anterior cruciate ligament (complete or partial); * Availability of an informed consent form signed and dated by the patient. * The patient's understanding of the strict requirements of the protocol, rehabilitation program and follow-up program and the desire to follow them. * The patient's consent to the use of the following drugs: nonsteroidal anti-inflammatory drugs (NSAIDs) (according to indications); antibiotics; anticoagulants. For collagen membrane of the first toe: * The type of degenerative disease of the first metatarsophalangeal joint is Hallux rigidus of stage 3-4. * Availability of an informed consent form signed and dated by the patient. * The patient's understanding of the strict requirements of the protocol, rehabilitation program and follow-up program and the desire to follow them. * The patient's consent to the use of the following drugs: nonsteroidal anti-inflammatory drugs (NSAIDs) (according to indications); antibiotics; anticoagulants Non-inclusion criteria: * Abuse of alcohol or narcotic substances (medicines). * Any clinically significant or symptomatic vascular or neurological disease of the lower extremities. * The presence of rheumatoid arthritis, parainfectious or infectious arthritis and the condition after the listed diseases, as well as the following diseases in the area of the damaged knee joint: septic arthritis, inflammatory joint disease, recurrent pseu…