CompletedPhase 2

Clemastine Fumarate in the Treatment of Neurodevelopmental Delays in Williams Syndrome

China28 participantsStarted 2024-03-20

Plain-language summary

This study focuses on therapeutic targets for cognitive, motor, and social impairments in Williams syndrome by reversing brain myelin defects caused by GTF2I. The primary objective of the study was to test and evaluate the initial efficacy and safety of Clomastine fumarate in the treatment of Williams syndrome.

Who can participate

Age range3 Years – 12 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age 3-12 years old;
✓. Positive fluorescence in situ hybridization (FISH) test confirmed Williams syndrome;
✓. GTF2I gene mutation was detected by whole exon;
✓. Heart safety variables are normal (e.g. normal ECG, blood pressure 120-129/80-84)

Exclusion criteria

✕. WS patients with other gene mutations;
✕. Used antihistamines, monoamine oxidase inhibitors, barbiturates and sedatives, as well as drugs affecting cognitive behavior, limb movement, white matter myelin, and MRI within 2 months before enrollment;
✕. Patients with narrow-angle glaucoma, narrow peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy and bladder neck obstruction; Accompanied by severe immunodeficiency disease;
✕. Allergic to Clomastine fumarate or other arylalkylamine antihistamines or any receptor;
✕. According to the recent interpretation of MRI and neuroradiology experts or WS, there are obvious brain lesions that are not related to WS disease;
✕. Clinically significant metabolic, hematological, liver, immune, urinary, endocrine, neurological, pulmonary, psychiatric, skin, allergic, renal, or other major diseases that may affect the interpretation of study findings or patient safety in WS's judgment;

What they're measuring

Anisotropy Score (FA)

Timeframe: baseline follow-up；D90; D194

Radial diffusion rate (RD)

Timeframe: baseline follow-up；second month；fourth month

axial diffusivity (AD)

Timeframe: baseline follow-up；D90；D194

mean diffusivity (MD)

Timeframe: baseline follow-up；D90; D194

Peabody（Motion Estimation Timewarp）score

Timeframe: baseline follow-up；second month；fourth month

Gesell Development Scale

Timeframe: baseline follow-up；second month；fourth month

quotients (IQs) of the WISC-IV

Timeframe: baseline; D90 ; D194

Trial details

NCT IDNCT06315699

SponsorQilu Hospital of Shandong University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-02

View on ClinicalTrials.gov More Williams Syndrome trials

Plain-language summary

Who can participate

Age range3 Years – 12 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Age 3-12 years old;
✓. Positive fluorescence in situ hybridization (FISH) test confirmed Williams syndrome;
✓. GTF2I gene mutation was detected by whole exon;
✓. Heart safety variables are normal (e.g. normal ECG, blood pressure 120-129/80-84)

Exclusion criteria

✕. WS patients with other gene mutations;
✕. Used antihistamines, monoamine oxidase inhibitors, barbiturates and sedatives, as well as drugs affecting cognitive behavior, limb movement, white matter myelin, and MRI within 2 months before enrollment;
✕. Patients with narrow-angle glaucoma, narrow peptic ulcer, pyloroduodenal obstruction, symptomatic prostatic hypertrophy and bladder neck obstruction; Accompanied by severe immunodeficiency disease;
✕. Allergic to Clomastine fumarate or other arylalkylamine antihistamines or any receptor;
✕. According to the recent interpretation of MRI and neuroradiology experts or WS, there are obvious brain lesions that are not related to WS disease;
✕. Clinically significant metabolic, hematological, liver, immune, urinary, endocrine, neurological, pulmonary, psychiatric, skin, allergic, renal, or other major diseases that may affect the interpretation of study findings or patient safety in WS's judgment;