A Study to Evaluate the Efficacy and Safety of Liso-cel Compared to Standard of Care in Adults Wi… (NCT06313996) | Clinical Trial Compass
WithdrawnPhase 3
A Study to Evaluate the Efficacy and Safety of Liso-cel Compared to Standard of Care in Adults With Relapsed or Refractory Follicular Lymphoma
Stopped: Replaced with another clinical trial.
0Started 2024-03-29
Plain-language summary
The purpose of this study is to evaluate the efficacy and safety of Liso-cel compared to standard of care in adults with Relapsed or Refractory Follicular Lymphoma.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria
* Participants must have measurable disease.
* Participants must have previously been treated with certain defined anti-cancer therapies and their disease must have come back or must have not responded to the previous or last treatment.
* Participants must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1.
* Participants that have histologically confirmed Follicular Lymphoma (FL) (Grade 1, 2, or 3a) corresponding to the most recent relapse prior to screening.
* Participants that have Relapsed or refractory FL, as assessed by the Investigator.
* Participants that have received at least one prior line and no more than three prior lines of systemic therapy including a combination of an anti-CD20 antibody and an alkylating agent.
* Participants that received one prior line of systemic therapy are eligible if they present with high risk features.
Exclusion Criteria
* Participants must not have any history of heart problems.
* Participants must not have any bleeding disorders.
* Participants must not have any Central Nervous System involvement by Follicular Lymphoma or other brain conditions.
* Other protocol-defined Inclusion/Exclusion criteria apply.
What they're measuring
1
Progression-free survival (PFS)
Timeframe: Up to 5 years from the last participant randomized
Trial details
NCT IDNCT06313996
SponsorJuno Therapeutics, Inc., a Bristol-Myers Squibb Company