Investigating the Impact of Indocyanine Green Titration on Fluorescent Intensity in Free Flap : An Exploration of Alternative Indicators

Inclusion Criteria: * Free flap operation that being performed by researchers. * Free Flap must have a skin paddle located on the body skin area with intraoperative ischemic time of at least 60 Minutes * Free flap should be in a viable/vital condition judged from the clinical examination of the flap, which includes color, temperature, turgor, capillary refill time (CRT), and skin prick test, immediately post surgery * Body area that will be a flap-free donor area has no history of trauma or operation * Patient with blood albumin value \>3 gr / dL * The patient/family sign the informed consent sheet stating willingness to become research sample Exclusion Criteria: * Patients have increased sensitivity to iodine or ICG * Free Flaps that being transported undergo trauma or damage due to external factors during treatment * Patient with high urea and creatinine level * Patient with high Alanine transaminase (ALT) and Aspartate transaminase (AST) level * Patients who receive injectable heparin treatment containing natrium disulfite preoperatively * Patients who regularly take anti-seizure drugs, haloperidol, heroin, meperidine, Metamizole, methadone, morphine, nitrofurantoin, opium, phenobarbital, and phenylbutazone.