During this 36-month R34 trial, eight study phases are proposed to adapt an evidence-based post traumatic stress disorder (PTSD) intervention (STAIR-NT) and layer it into a methadone maintenance treatment (MMT) program (START Treatment and Recovery centers) in New York City for use among individuals engaged in stimulant-opioid polysubstance use. The study aims to adapt STAIR-NT to a massed treatment schedule. Once an adapted protocol is complete, it will be tested for feasibility, acceptability, and short-term polysubstance and PTSD symptomology outcomes in a pilot randomized control trial (RCT) of 80 participants. Participants who screen eligible and consent will be randomized 1:1 to the adapted STAIR-NT intervention or treatment as usual (TAU) using randomization blocks of two and two and four via a computer-generated randomization sequence. Participants assigned to the intervention will receive the adapted massed delivery of STAIR-NT by trained counselors.
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Proportion of Eligible Participants
Timeframe: Baseline
Proportion of Eligible Participants who Enroll
Timeframe: Baseline
Number of Intervention Sessions Completed
Timeframe: Up to Month 3
Clinician-Rated Feasibility of Intervention Measure (FIM) Score
Timeframe: Month 3
Clinician-Rated Feasibility of Acceptability of Intervention Measure (AIM) Score
Timeframe: Month 3
Number of Days of Co-Use of Cocaine and Illicit Opioids
Timeframe: Month 3
Number of Substances Used based on ASI Self-Report
Timeframe: Month 3
Number of Substances Used based on Urine Drug Screen
Timeframe: Month 3
Number of Substances Used based on Chart Abstraction of Toxicology Results
Timeframe: Month 3
PTSD Checklist for DSM-5 (PCL-5) Score
Timeframe: Month 3
Negative Mood Regulation Scale Score
Timeframe: Month 3
Inventory of Interpersonal Problems Score
Timeframe: Month 3