A bidirectional relationship among nutrition, infection and immunity exists: changes in one component affect the others. Various micronutrients are essential for immunocompetence, particularly vitamins A, C, D, E, B2, B6, and B12, folic acid, iron, selenium, and zinc. Micronutrient deficiencies are a recognized global public health issue, and poor nutritional status predisposes to certain infections. Immune function may be improved by restoring deficient micronutrients to recommended levels, thereby increasing resistance to infection and supporting faster recovery when infected. Diet alone may be insufficient and tailored micronutrient supplementation based on specific age-related needs is necessary. Aim of the study is to investigate whether nutrient supplementation may affect different functional parameters of the innate and adaptive immunity.
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Change in neutrophil chemotaxis
Timeframe: Basal, after 12 and 24 days treatment
Change in neutrophil phagocytosis
Timeframe: Basal, after 12 and 24 days treatment
Change in neutrophil oxidative burst
Timeframe: Basal, after 12 and 24 days treatment
Change in mononuclear CD4pos69pos
Timeframe: Basal, after 12 and 24 days treatment
Change in mononuclear CD56pos69pos granzymepos
Timeframe: Basal, after 12 and 24 days treatment
Change in plasma cytokine levels
Timeframe: Basal, after 12 and 24 days treatment