Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement (NCT06302296) | Clinical Trial Compass
RecruitingNot Applicable
Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement
Syria14 participantsStarted 2025-12-20
Plain-language summary
One of the main goals of orthodontic treatment is the reduction of treatment time through faster tooth movement. The previous studies evaluating platelet-rich fibrin (PRF) and orthodontic tooth movement (OTM) are limited, which makes the results difficult to generalize.
Who can participate
Age range18 Years – 26 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* The patient's age (18-26). Severe or very severe irregularity of the upper incisors greater than (7 mm) according to Little's index, so it is recommended to extract the upper first premolar.
* Class I or Class II malocclusion, first model according to Angle, with skeletal class I or II and a normal or mild vertical growth pattern.
* All permanent upper teeth, up to the first molar, are present, with the possibility of attaching brackets to all teeth in a correct position.
* The patient has good oral health.
Exclusion Criteria:
* • The presence of any systemic disease that affects orthodontic dental movement.
* Severe malalignment of one of the teeth (palatal quadrant, ectopic canine, ectopic premolar).
* The patient has undergone previous orthodontic treatment.
* The patient is subject to any drug treatment that may affect orthodontic dental movement (cortisone, non-steroidal anti-inflammatory drugs).
* The patient has poor oral health.
* Commitment to periodic follow-up appointments.