Immunogenicity and Safety of Inactivated and Live-attenuated HAV Vaccine Among Thai Healthy Children and Adolescents

Inclusion Criteria: * Age between 18 months and 18 years * Has healthy status * Has no history of hepatitis A infection or previous hepatitis A disease * Has never received hepatitis A vaccine (from vaccine booklet or parental history) * Participants and/or caregivers gives written inform consent/assent form Exclusion Criteria: * Has acute illness within 4 weeks before enrollment * Has fever with jaundice within 4 weeks before enrollment * Has underlying disease of thrombocytopenia, coagulopathy, hemophilia A or B, neurologic disease, immunocompromised condition, chronic liver disease, chronic hepatitis B or C infection * Has received immunosuppressive agents or immunomodulatory agents, corticosteroid \>2 mg/kg/day or 20 mg/day within 6 months before enrollment * Has received blood or blood component, or intravenous immunoglobulin within 6 months before enrollment * Has received any lived-attenuated vaccine within 30 days before enrollment * Has history of severe allergy to vaccine or vaccine component, including aluminum hydroxide, 2-phenoxyethanol, neomycin, formaldehyde, gentamicin sulfate, or has history of anaphylaxis or severe allergic reactions following vaccination * Women planning for pregnancy, pregnant women or lactating women * Women in childbearing age who cannot use contraceptive methods during study participation * Is concurrently involved in other clinical trials in which receiving an investigational vaccine or study drug as part of study participation * Ha…