The goal of this clinical trial is to clarify (i) the contribution of brain insulin action on regulation of systemic metabolism, (ii) sex-specific differences in the central regulation and (iii) the influence of the menstrual cycle in women. Therefore, participants will undergo oral glucose tolerance tests combined with a double tracer dilution technique. This approach will be compared between days with insulin delivery to the brain as nasal spray and days with placebo spray.
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Endogenous glucose production
Timeframe: -120 minutes - 180 minutes during oral glucose tolerance test
Rate of glucose disappearance
Timeframe: -120 minutes - 180 minutes during oral glucose tolerance test