Clinical outcomes after surgical resection in HCC is a continuum and is clearly related to tumor burden but needs better definition. The researchers describe the use of the "metro ticket" approach to analyze surgical outcomes over the whole spectrum of anatomically resectable HCC to define overall survival including intermediate stage tumors (BCLC B). The analysis the researchers provide in this study enables the clinician to select the optimal surgical resection candidate based on robust long term survival data. In addition, study compares outcome for open surgery vs laparoscopic surgery, survival outcome for viral and non-viral HCC using Albumin-Bilirubin (ALBI) for more comprehensive study result. On top of that, non-HBV, non-HCV (NBNC) hepatocellular carcinoma (HCC) is generally associated with poorer tumor characteristics. However, it remains unclear whether this leads to worse post-resection survival compared to viral-related HCC. This study evaluates the prognostic impact of viral status and liver function on post-resection survival outcomes between NBNC and viral HCC patients. This retrospective study also aims to determine if HCC of viral and non-viral etiologies have different clinical outcomes after surgical resection when tumor burden and liver function are considered.
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5-year mortality.
Timeframe: At least 5 years.
Concordance of pre-operative radiological and post operative surgical specimen.
Timeframe: Through study completion, an average of 3 years.
Agreement between TBI calculated from pre-operative imaging versus those obtained from post-surgical pathological assessment.
Timeframe: Through study completion, an average of 3 years.
Overall survival (OS) stratified on hepatitis status.
Timeframe: Minimum 2 years follow up after Hepatocellular carcinoma resection.
Recurrence-free survival (RFS) stratified on hepatitis status.
Timeframe: Minimum 2 years follow up after Hepatocellular carcinoma resection.
Prognostic stratification according to ALBI grade.
Timeframe: Minimum 2 years follow up after Hepatocellular carcinoma resection.