CPAP in Patients With Severe Obesity After Anesthesia (NCT06287632) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
CPAP in Patients With Severe Obesity After Anesthesia
60 participantsStarted 2026-06
Plain-language summary
The goal of this study is to compare two continuous positive airway pressure (CPAP) settings on heart and lung function in patients with severe obesity after anesthesia. The main questions it aims to answer are:
1. Does a recruitment maneuver and CPAP set to intrathoracic pressure (ITP) improve cardiopulmonary function compared to standard CPAP settings in patients with severe obesity after anesthesia?
2. Does the location of adipose tissue influence the response to CPAP settings in patients with severe obesity after anesthesia?
Participants will undergo monitoring of their intrathoracic pressure using an esophageal catheter. In the recovery area after anesthesia, participants will receive two CPAP settings, each for 20 minutes.
* Intervention 1: Recruitment maneuver and CPAP will set to the level of intrathoracic pressure
* Intervention 2: CPAP set to home settings (if OSA is present) or between 8-10 cmH20 (if OSA is not present).
Who can participate
Age range18 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Adult patients (≥ 18 years old) scheduled for elective non-cardiothoracic surgery requiring general anesthesia with an endotracheal tube
✓. Planned admission to the post-anesthesia care unit (PACU) after surgery
✓. BMI ≥ 40 kg/m2
✓. At the time of baseline measurements in the PACU, patients meet the following criteria:
Exclusion criteria
✕. Pregnancy, suspected pregnancy or less than six weeks postpartum Known or current pneumothorax
✕. Hemodynamic instability at the time of study assessment in the PACU defined as:
✕. Respiratory insufficiency in PACU defined as:
✕. Known chronic lung disease requiring supplemental oxygen at home
✕. Contraindication for esophageal catheter placement:
What they're measuring
1
End expiratory lung impedance
Timeframe: Assessed at baseline during atmospheric pressure breathing (no CPAP), assessed at the end of intervention A (20 minutes), assessed at end of intervention B (20 minutes)