Cardiovascular Metabolic Remodeling in Shock (NCT06285513) | Clinical Trial Compass
UnknownNot Applicable
Cardiovascular Metabolic Remodeling in Shock
France50 participantsStarted 2024-09
Plain-language summary
The aim of the study is to increase our knowledge of energy dysfunction in the cardiovascular dysfunction observed during shock states by analysing the omics molecules involved.
Who can participate
Age range18 Years – 75 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patient aged between 18 and 75.
* Patient admitted to intensive care for shock treated with a vasoactive or inotropic amine (adrenaline, dobutamine or noradrenaline).Patient undergoing invasive mechanical ventilation for less than 24 hours (or admitted to intensive care for less than 24 hours if the patient arrived intubated) and for a foreseeable duration of ventilation of at least 48 hours.
* Patient, or relative if the patient is not competent, who has read and understood the information letter and does not object to participation in the research, or emergency procedure in the absence of a relative.
* Urine or blood pregnancy test if a sample is taken as part of routine negative care (if woman of childbearing age).
Exclusion Criteria:
* Moribund patient (death expected within \< 24 hours) and/or decision to limit or stop treatment on admission to intensive care.
* Pregnant, parturient or breast-feeding woman.
* Patient not suitable for enteral calorie intake. Patient with a history of: advanced chronic renal failure ; advanced chronic liver failure.
* Incapacitated patient of full age (under guardianship, curatorship) or deprived of liberty by court order.
* Patient already taking part in an interventional study.
What they're measuring
1
Evaluation of the prognostic capacity of the initial metabolomic profile of patients in shock