This is a randomized observational study. The main aim is to determine potential oocyte competence predictive mRNA expression profiles in the cumulus cells isolated form individual oocytes. In 2 patient cohorts: 1)GnRH Antagonist \& hr-FSH with GnRH Agonist trigger, 2) Progesterone \& hr-FSH with GnRH Agonist trigger.
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Basic clinical donor patient and stimulation characteristics: P4
Timeframe: During ovarian stimulation (max 3 weeks)
Basic clinical donor patient and stimulation characteristics: E2
Timeframe: During ovarian stimulation (max 3 weeks)
Basic clinical donor patient and stimulation characteristics: Gonadotropin type and dose
Timeframe: During ovarian stimulation (max 3 weeks)
Clinical evaluation: number of Follicles
Timeframe: During ovarian stimulation (max 3 weeks)
Clinical evaluation: number of cumulus-oocyte complex
Timeframe: Day 1 of embryo culture
Clinical evaluation: Meiosis II oocytes
Timeframe: Day 1 of embryo culture
Clinical evaluation: Abnormal fertilization
Timeframe: Day 1 of embryo culture
Clinical evaluation: Normal Fertilization
Timeframe: Day 1 of embryo culture
Clinical evaluation: Day 3 embryo evaluation
Timeframe: Day 3 of embryo culture
Clinical evaluation: Day 5/6 embryo evaluation
Timeframe: Day 6 of embryo culture
Clinical evaluation: Day5/6 good quality blastocyst rate
Timeframe: Day 6 of embryo culture
Clinical evaluation: Embryo utilization
Timeframe: Day 6 of embryo culture
Expression profile: blastocyst formation
Timeframe: 2.5 years after study start