From Fetal-maternal Interface Immune Tolerance to Endometrial Cancer Immune Escape: Potential Targets for Immunotherapy

Inclusion Criteria: * Age \>18 years; * Histological diagnosis of endometrial hyperplasia with and without atypia, carcinoma of the endometrium histotype endometrioid at any stage of the disease (FIGO I-IV), patients subjected to hysterectomy for benign extra-endometrial pathology, patients with recurrence/metastasis from endometrioid endometrial carcinoma that are subjected to surgery; * Adequate biological material to be able to carry out the analyzes previously described; * Written informed consent (only for patients in the prospective part and/or in follow-up); * For the retrospective part: availability of samples adequately stored at the Institute biobank and availability of follow-up data. Exclusion Criteria: * Comorbidities not controlled with adequate medical therapy; * Infections of the endometrial cavity (pyometra); * Synchronous tumors; * Neoadjuvant treatments; * Previous radiation treatments on the pelvic region.