Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin (NCT06272994) | Clinical Trial Compass
CompletedNot Applicable
Swab Testing to Optimize Pneumonia Treatment With Empiric Vancomycin
United States277 participantsStarted 2024-04-03
Plain-language summary
This is a single center, pragmatic, randomized clinical trial (pRCT) examining whether reporting the results of a negative rapid PCR back to the provider via a pager alert results in decreased vancomycin utilization for critically ill adults with community-acquired pneumonia when compared with usual care.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Adult (age greater than or equal to 18) patients admitted/transferred to the Vanderbilt University Medical Center (VUMC) Medical Intensive Care Unit (MICU) from the VUMC Emergency Department or from a hospital floor within 48 hours of admission.
* Suspicion for pneumonia on admission (defined as an indication for antibiotics of "respiratory infection" and/or an order for a respiratory culture i.e., sputum culture, tracheal aspirate culture, or bronchoalveolar lavage (BAL) culture).
* No topical nasal decolonization during hospitalization prior to collection of MRSA nasal swab PCR.
* Must match both of the following in either order:
* The patient has been admitted to and physically located in the MICU.
* The patient has received a continuing vancomycin order, or a pharmacokinetics consult for a continuing vancomycin order, no later than 24 hours following their physical admission to the MICU.
Exclusion Criteria:
* Hospital stay of longer than 48 hours prior to MICU admission.
* Known to be a prisoner
What they're measuring
1
Vancomycin-free Hours Alive
Timeframe: Baseline to seven days following enrollment.