The primary objective of this study is to investigate the feasibility of a multimodal prehabilitation programme consisting of MIET during neoadjuvant intravenous chemotherapy infusion, HITT and strength training during the last six weeks prior to surgery, and optimising nutritional intake throughout the total preoperative period in patients with breast cancer with respect to recruitment, adherence, dropout, safety and acceptance. The secondary objective is to provide a preliminary evaluation of participant responses to a preoperative multimodal lifestyle intervention, on cardiorespiratory fitness, muscle strength, nutritional status, and fatigue in patients with breast cancer receiving neoadjuvant chemotherapy.
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Recruitment rate (%)
Timeframe: Week 0
Characteristics of included participants
Timeframe: Week 0
Attendance rate for MIET sessions (%)
Timeframe: Week 10-20
Adherence rate, exercise relative dose intensity (ExRDI) MIET (%)
Timeframe: Week 10-20
Reasons for not having executed a training session as intended
Timeframe: Week 10-20
Attendance rate HIIT + strength sessions (%)
Timeframe: Week 17-22
Adherence rate, ExRDI HIIT training (%)
Timeframe: Week 17-22
Adherence rate, ErXDI strength training (%)
Timeframe: Week 17-22
Attendance rate for dietary consultations (%)
Timeframe: Weeks 9, 15, 20 and 22
Percentage of use of the digital food diary 'Mijn Eetmeter'(%)
Timeframe: Weeks 15, 20 and 22
Percentage of days on which nutritional requirements were achieved (%)
Timeframe: Weeks 15, 20 and 22
Reasons for not achieving the nutritional requirements as intended
Timeframe: Weeks 15, 20 and 22
Drop-out rate (%)
Timeframe: Week 1-22
Time point of drop-out
Timeframe: Week 1-22
Reasons for drop-out
Timeframe: Week 1-22
Serious adverse events (SAE)
Timeframe: Week 10-22
Study related adverse events
Timeframe: Week 10-22
Acceptance - Experiences with the multimodal lifestyle intervention
Timeframe: Week 22
Acceptance - Suitability of the multimodal lifestyle intervention and study procedures
Timeframe: Week 22
Acceptance - Barriers and enablers regarding participation in the study
Timeframe: Week 22