The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persi… (NCT06264154) | Clinical Trial Compass
RecruitingNot Applicable
The Role of Flavor in the Substitutability of E-cigarettes for Combustible Cigarettes Among Persistent Smokers
United States210 participantsStarted 2024-08-26
Plain-language summary
This between-subjects study aims to evaluate the effect of flavor on initial and sustained switching from combustible cigarettes to e-cigarettes among 210 cigarette smokers. After measuring baseline cigarette smoking rate, participants will be randomized to a six-week regimen of fruit-flavored, tobacco-flavored, or menthol-flavored e-cigarettes and be instructed to switch (versus smoking cigarettes) over a 6-week period. Flavor-associated subjective reward and the reinforcing value of flavored e-cigarettes relative to combustible cigarettes will be assessed as mechanisms.
Who can participate
Age range21 Years
SexALL
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Inclusion criteria
✓. Able to communicate fluently in English (i.e. speaking, writing, and reading)
✓. Male and female smokers who are \> 21 years of age and self-report smoking at least 5 cigarettes (menthol and/or non-menthol) per day for at least the last 12 months
✓. 5 or more failed quit attempts and the use of smoking cessation medication on at least one prior attempt.
✓. Ever use of an e-cigarette
✓. Have a carbon monoxide (CO) greater than 10 ppm
✓. Not using any forms of nicotine regularly other than cigarettes
✓. Be willing to switch to e-cigarettes for 6 weeks and use the assigned flavors
✓. Plan to live in the area for the duration of the study
Exclusion criteria
✕. Participants agreeing to abstain from using nicotine-containing products other than cigarettes for the duration of the study will be considered eligible.