CompletedNot Applicable

Cardiopulmonary Bypass and Ventricular Remodeling

Chile12 participantsStarted 2021-10-04

Plain-language summary

The goal of this observational study is determine if reduced ventricular ejection fraction is a factor that determines a pro-oxidant imbalance in patients subjected to cardiac surgery with cardiopulmonary bypass. The main questions are: * 1\. Preoperative reduced left ventricular function determines higher blood and atrial tissue oxidative stress in patients subjected to cardiopulmonary bypass * 2\. Oxidative stress markers in atrial tissue of cardiac surgical patients with develop atrial fibrillation The main tasks participants will be asked to do is register the symptoms of arrhythmia and heart failure. Also, obtain a electrocardiographic register if any present palpitations or chest pain with clinical significance This study not present a comparison group.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * age ≥18 years, chronic heart failure (WHO-functional class II, III) for at least 3 months before surgery. At the baseline visit, 7-10 days before surgery, the patients were classified by echocardiography as HF with pLVEF (LVEF \>40%) or HF with rLVEF (LVEF ≤40%). Exclusion Criteria: * Patients with history or evidence of AF, previous myocardial infarction, current use of amiodarone, severe congestive heart failure (New York Heart Association class III or IV), presence of prosthetic valves, congenital valvular disease, chronic rheumatic, neoplastic diseases, liver insufficiency, severe chronic kidney disease (serum creatinine \>2.5 mg/dl), recent infections ( 2 weeks) and emergency surgery or repair of cyanotic heart disease. In addition, patients receiving nonsteroidal anti-inflammatory drugs, corticosteroids, antioxidants, vitamins, or fish oil supplements, three months before surgery were also excluded.

What they're measuring

Postoperative atrial fibrillation

Timeframe: cardiac recording monitoring from surgery until the fifth postoperative day

Trial details

NCT IDNCT06256965

SponsorUniversity of Chile

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2021-11-15