Clinical and Histological Study of a Novel Dermal Substitute

Inclusion Criteria: * Age: 1 to 75 years * Full-thickness skin defect qualifying for coverage with the dermal substitute NovoSorb® BTM before transplantation with a STSG: * Acute cases: burn injury, soft tissue injury, skin necrosis after purpura fulminans or similar condition * Reconstructive cases (elective surgery): e.g. scar formation after burn injury, giant congenital nevus, defect after removal of skin tumor, skin defect due to other surgical procedures * Documented medical treatment decision of covering the full-thickness skin defects with either the two-step BTM/STSG procedure or with STSG alone or by using both techniques on different wound areas * Informed consent by patients/parents or other legal representative Exclusion Criteria: * Infected wounds needing surgical procedure other than a dermal template * Patients with known underlying or concomitant medical conditions that may interfere with normal wound healing (e.g. immune deficiency, systemic skin disease, any kind of congenital defect of metabolism including diabetes) * Previous enrolment of the patient into the current study * Adolescent/Adult patients or in case of children their parents/legal representatives unable to comply with the study protocol * Pregnant or breast feeding females