Stopped: Institutional Review
This phase II trial tests how well atezolizumab works in treating patients with human papillomavirus (HPV) related oropharyngeal squamous cell carcinoma that is able to be removed with surgery (resectable). Immunotherapy with atezolizumab, may include changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread.
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Incidence of treatment-emergent adverse events
Timeframe: From the first dose of study drug to 30 days after the last dose of the study drug
Pathologic response
Timeframe: After cycle 2 (each cycle is 21 days) and prior to surgery (for ctDNA changes) and on final pathologic analysis 14 days after surgery
Event-free survival (EFS)
Timeframe: From the first administration of atezolizumab to date of recurrence, death or up to 2 years