Oral PEG vs. Enema in Urgent Colonoscopy for ALGIB (NCT06254443) | Clinical Trial Compass
CompletedNot Applicable
Oral PEG vs. Enema in Urgent Colonoscopy for ALGIB
China144 participantsStarted 2024-01-08
Plain-language summary
The main goal of this study is to assess whether the diagnostic efficacy of enema is non-inferior to that of oral polyethylene glycol (PEG) in acute lower gastrointestinal bleeding (ALGIB) patients requiring urgent colonoscopy. The secondary objectives include: 1) evaluating potential differences between the enema and oral PEG groups in terms of the difficulty and safety of colonoscopy, as well as exacerbation of bleeding; 2) conducting subgroup analyses to compare the effectiveness of the two bowel preparation methods in specific populations, exploring potential candidate groups for different bowel preparation strategies, and promoting individualized diagnosis and treatment for ALGIB.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Had the last bloody bowel movement within 24 hours of presentation;
✓. Aged 18 years or over
✓. Had indications for clinical colonoscopy
Exclusion criteria
✕. Known or suspected upper gastrointestinal bleeding meeting any of the following criteria:
✕. Previous colonoscopy has been performed at an external institution with a confirmed diagnosis.
✕. Presence of primary or secondary coagulation disorders.
✕. History of bowel diversion surgery (including partial colon resection).
✕. Hemodynamic instability persists after fluid resuscitation (shock index greater than 1).
✕. Interventional treatment has been performed and hemostasis has been successfully achieved.
✕. Requires transfer to an intensive care unit due to the severity of the condition.
What they're measuring
1
Endoscopic diagnosis rate
Timeframe: During the colonoscopy (up to 48 hours from admission)