Effectiveness and Safety of Collagen Membrane (FormaAid®) in the Treatment of Periodontal Regeneration

Inclusion Criteria: * Age between 18 70 years old, male or female * Non current smoker: A person who has not smoked more than 100 cigarettes from the past to the present and has not smoked in the last 30 days. * Patients who have decided to pay at their own expense and require guided tissue regeneration (GTR) for periodontal regeneration * The defect morphology of intrabony defects is 2 or 3 wall intrabony defect. * Periodontal pocket depth ≥ 5mm (probing periodontal depth, PPD, distance from gingival margin to the bottom of the defect). * The height of the bone defect in the X ray image is ≥ 3mm (according to the X ray film intraosseous defect) * The diagnosis of periodontal disease is stage III with either grade B or C. * Patients who are willing to adhere to the study protocol and sign the informed consent form. * Willing to accept evaluation during the trial period and return to clinic and treatment. * Not a person subject to a sentence of guardianship or subject to judicial guardians. Exclusion Criteria: * Have a history of severe allergies or be allergic to collagen. * Those who are known to be positive for human immunodeficiency virus. * Poorly controlled diabetes (untreated or unstable disease status), blood test measurement of glycated hemoglobin greater than 7% * Undergoing chemotherapy three months before agreeing to this experiment. * Patients undergoing meat product desensitization treatment. * Have a documented history of osteoporosis. * Chronic disease, hype…