This interventional study aims to investigate the therapeutic efficacy of Cognitive multi-sensory rehabilitation (CMR) on upper limb function and fatigue in chronic stroke patients. The main question is: • Does cognitive multi-sensory rehabilitation significantly affect upper limb function and fatigue in stroke patients? Participants will be assigned into two groups. They will receive 12 sessions of study group CMR and traditional physical therapy and control group traditional physical Therapy rehabilitation. CMR 40 minutes immediately followed by 20 minutes of selected physical therapy program, three sessions per week for four weeks.
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Fugl-Meyer Assessment for upper extremity (FMT-UE).
Timeframe: from baseline to four weeks after the beginning of intervention
Serum levels of Brain-Derived Neurotrophic Factor (BDNF)
Timeframe: from baseline to four weeks after the beginning of intervention
Changes in hand grip strength
Timeframe: from baseline to four weeks after the beginning of intervention
Fatigue Assessment Scale (FAS)
Timeframe: from baseline to four weeks after the beginning of intervention