Stopped: Not activated at the site level
This study will evaluate a new form of non-invasive deep brain therapy for food addiction. Low-intensity transcranial focused ultrasound stimulation will first be delivered using a range of stimulation parameters during psychophysical and physiological monitoring. A well-tolerated stimulation protocol will be selected for subsequent testing in a blinded randomized sham-controlled trial. The trial will evaluate brain target engagement using magnetic resonance imaging, Food Cravings Questionnaire-State, and changes in subject's weight over the course of the study.
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Change in body weight (%) from baseline week 0 to week 16
Timeframe: The body weight will be taken prior to each intervention (once per week)
Number of participants who achieved body weight reduction >= 5%
Timeframe: Assessment at week 16
Food Cravings Questionnaire-State
Timeframe: During and immediately after each weekly intervention
Hamilton Depression Rating Scale, 17 item
Timeframe: For up to 16 weeks