The Analysis of Risk Factors for Recurrent Pregnancy Loss and Prediction of Pregnancy Loss Risk (NCT06249230) | Clinical Trial Compass
UnknownNot Applicable
The Analysis of Risk Factors for Recurrent Pregnancy Loss and Prediction of Pregnancy Loss Risk
China1,000 participantsStarted 2024-01-31
Plain-language summary
Based on the comprehensive etiological screening results of patients with recurrent pregnancy loss, including basic characteristics, coagulation function indicators, autoimmune indicators, endocrine indicators, and gynecological ultrasound examination results, as well as the outcome of subsequent pregnancy after the patient's visit, analyze the independent risk factors affecting recurrent pregnancy loss, construct and validate an abortion risk prediction model to predict the risk of subsequent pregnancy loss in patients with recurrent pregnancy loss, and classify the patient's risk, Screening high-risk populations and guiding clinical early intervention and active treatment to improve pregnancy success rates.
Who can participate
Age range20 Years ā 50 Years
SexFEMALE
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Inclusion criteria
ā. Diagnosis of recurrent miscarriage: patients who had two or more spontaneous miscarriages (including biochemical pregnancies, excluding spontaneous miscarriages due to chromosomal abnormalities in the embryo) before 28 weeks of gestation with the same partner prior to the consultation were included in this study;
ā. ā„20 years old;
ā. Completion of initial history taking and complete results of the etiological screening programme;
ā. Knowledge of the purpose and significance of the study, consent and sign the informed consent form;
Exclusion criteria
ā. Pregnant at the first visit;
ā. Presence of severe contraindications to pregnancy, making it inadvisable to conceive;
ā. Voluntary withdrawal from the pregnancy or from the study;
ā. No pregnancy outcome as of the follow-up endpoint (December 31, 2023), indicating no pregnancy;
ā
What they're measuring
1
Number of participants with pregnancy success
Timeframe: Follow-up to 32 weeks of gestation for live intrauterine pregnancies or follow-up cut-off
2
Number of participants with pregnancy loss
Timeframe: The time of spontaneous abortion occurring before 28 weeks of gestation after consultation
. Loss to follow-up, unable to obtain pregnancy outcome;
ā. Subsequent pregnancy outcomes after the clinic visit included ectopic pregnancy, molar pregnancy, fetal malformations, and pregnancy at the scar site of previous cesarean section.