No accepted clinical therapies exist for repair of motor pathways following spinal cord injury (SCI) in humans, leaving permanent disability and devastating personal and socioeconomic cost. A robust neural repair strategy has been demonstrated in preclinical studies, that is ready for translation to recovery of hand and arm function in human SCI, comprising daily transcranial magnetic stimulation treatment at the inpatient rehabilitation facility. This study will establish clinical effect size of the intervention, as well as safety and feasibility necessary for a subsequent controlled efficacy trial and inform preclinical studies for dosing optimization.
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Eligibility - (Percentage candidates eligible of screened patients)
Timeframe: 21 months (Recruitment period)
Recruitment - (Percentage candidates enrolled of approached patients)
Timeframe: 21 months (Recruitment period)
Adherence to intervention - (Percentage candidates who dropout during the intervention period of enrolled candidates)
Timeframe: 2 years (Duration of human subjects' involvement)
Adherence to outcome assessment - (Percentage candidates who do not complete outcome assessments of enrolled candidates)
Timeframe: 2 years (Duration of human subjects' involvement)
Retention - (Percentage candidates who do not complete 6-month follow up of enrolled candidates)
Timeframe: 2 years (Duration of human subjects' involvement)
Adverse Events
Timeframe: 2 years (Duration of human subjects' involvement)