Finerenone and Renal Oxidative Stress

Inclusion Criteria: * Age of 18 - 75 years * Diagnosis of type 2 diabetes mellitus (defined by ADA criteria) * Male and Female patients (females of child bearing potential must be using effective contraceptive precautions per CTFG quidance) * Females of childbearing potential or within two years of the menopause must have a negative urine pregnancy test at screening visit * Informed consent (§ 40 Abs. 1 Satz 3 Punkt 3 AMG) must be given in written form Exclusion Criteria: * Any other form of diabetes mellitus than type 2 diabetes mellitus * Female who is pregnant, breast feeding or intends to become pregnant. Documentation of highly effective contraception is required for women of childbearing potential. Women of child-bearing potential, defined as all women physiologically capable of becoming pregnant, unless they are using highly effective methods of contraception while taking study treatment and for 3 months after stopping medication * Use of insulin or GLP-1 analogue within the past 3 months * HbA1c ≥ 10.5% * Serum potassium \> 4.8 mmol/l * Body mass index \> 40 kg/m² * Estimated glomerular filtration rate (eGFR) \< 45 ml/min/1.73m² (CKD-EPI Formula) * Uncontrolled arterial hypertension (BP ≥ 180/110 mmHg) * Subclinical or clinical hyperthyroidism * Significant laboratory abnormalities such as serum Glutamate-Oxaloacetate-Transaminase (SGOT) or serum Glutamate-Pyruvate-Transaminase (SGPT) levels more than 3 x above the upper limit of normal range * Use of strong CYP3A4…