Simeox Therapy at Home Versus Standard of Care in NCFB Patients With CMH

Inclusion Criteria: * Patient with confirmed diagnosis of bronchiectasis confirmed by High Resolution Computed Tomography (HRCT): idiopathic, post-infective, systemic disease, ABPA, asthma, COPD, PCD * Overproduction of mucus (ie: estimated bronchorrhea \>10mL/day). * Pulmonary exacerbation (in- or outpatients) * Age \> 18 years old * Patient able to understand the study and to perform the 2-month follow up visit Exclusion Criteria: * Pneumothorax/pneumo-mediastinum in the six months prior hospitalization * Recent episode of severe haemoptysis * Unstable severe cardiac disease or hemodynamic instability * Cystic fibrosis or COPD as dominant diagnosis * Patient on lung transplant list * Severe lung injuries * Recent lung surgery * Inhalation support (continuous ventilatory support) * Tracheostomy * Uncontrolled GERD * Any contraindication to an instrumental bronchial clearance technique (up to the investigator) * Inability to perform PFT or 6MWT * Patient not available or wishing to move to a different region within 2 months of inclusion * Patient considered by the investigator to be physically or mentally inapt to use the device and/or to perform the study procedures. * Patient currently participating or having participated within one month prior to inclusion in a clinical intervention research trial that may impact the study, the impact of which is up to the investigator