Smartphone App-guided Inspiratory Muscle Strength Training for Lowering Systolic Blood Pressure

Inclusion Criteria: * Age 18+ years * Ability to provide informed consent * Willing to accept random assignment to condition * Systolic blood pressure 120-160 mmHg * Owns an Apple or Android smartphone * Body mass index \<40 kg/m2 * Subject report of being weight stable in the prior 3 months (\<2 kg weight change) and willing to remain weight stable during the 6-week intervention period * Subjects taking antihypertensive medications will be included provided they meet the other inclusion criteria, including systolic blood pressure. Medication regimen (prescription and dosing) must be stable for at least 3 months prior to enrollment in the study and must remain stable during the 6-week intervention period. These medications will not be withheld prior to experimental protocols. * If woman of childbearing age: * Not pregnant (defined as self-report of pregnancy) * Willing to be abstinent or use approved contraception (i.e., hormonal contraception, intrauterine devices, barrier methods such as condoms with spermicide, and surgical sterilization) throughout the duration of the study Exclusion Criteria: * Age \<18 years * Participant report of a chronic overt medical condition (e.g., unstable cardiovascular disease, recent myocardial infarction or stroke, cancer) that may make it unsafe to participate in the study under the discretion of the study Medical Director. * Inability to abstain from consumption of alcohol for 12 hours on experimental days. * Report of blood donati…