A Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmaco… (NCT06229548) | Clinical Trial Compass
CompletedPhase 1
A Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SYH2053
China39 participantsStarted 2024-01-08
Plain-language summary
This is a randomized, double-blind, placebo-controlled, single ascending dose (SAD) study of SYH2053 when administered subcutaneously to subjects with normal and elevated LDL-C.
Who can participate
Age range18 Years – 60 Years
SexALL
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Inclusion criteria
✓. Subjects must give informed consent before the trial, fully understand the content, procedures and possible adverse reactions, and voluntarily sign a written informed consent.
✓. Sex: male or female subjects.
✓. Age of 18 - 60 years (inclusive).
✓. BMI: 18.6-28.5 kg/m\^2 (inclusive), with a minimum weight of 50 kg (inclusive) for male and 45 kg (inclusive) for female.
✓. During screening and baseline, LDL-C ≥100 mg/dL (2.6 mmol/L) and \< 190 mg/dL (4.9 mmol/L); TG ≤ 400 mg/dL (4.5 mmol/L); TC \< 278 mg/dL (7.2 mmol/L) in serum under fasting state;
✓. Subjects have no history of chronic or serious diseases or family history of early-onset coronary heart disease, including cardiovascular, liver, kidney, blood and lymphatic, endocrine, immune, psychiatric, neurological, and gastrointestinal systems, and are generally in good health.
✓. The subjects can communicate well with the investigators and complete the trial according to the protocol.
Exclusion criteria
✕. Allergic constitution or known history of allergy to the components of the study drug or similar drugs.
✕. Antibody drugs targeting PCSK9 have been used within 6 months prior to screening, oligonucleotides targeting PCSK9 have been used within 12 months prior to screening.
✕. There are currently medical disorders of clinical significance, including but not limited to, circulatory, hematological or hematopoietic diseases, respiratory, endocrine, urinary, digestive, neurological or psychiatric disorders, infections, tumors, severe trauma, or any other diseases that the investigator considers to be excluded or likely to interfere with the interpretation of the findings.
What they're measuring
1
The Number of Participants with Treatment Related Adverse Events as Assessed by CTCAE v5.0
Timeframe: Pre-dose and multiple timepoints no less than 57 days
✕. Those who underwent major surgery within 6 months prior to initial administration, or who planned to undergo surgery during the study.
✕. Clinically significant abnormalities in vital signs, physical examination, electrocardiogram and laboratory examination.
✕. The estimated glomerular filtration rate (eGFR) during screening was \< 90 mL/min/1.73 m\^2 (calculated by simplified MDRD formula).
✕. During screening, any item of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBIL), γ-glutamyltransferase (GGT), alkaline phosphatase (ALP) \> 1.5×ULN (retest once within 1 week allowed).
✕. During screening or baseline, subjects with prolonged QT/QTc interval (QTcF \> 450 ms in male, \> 470 ms in female).