Orelabrutinib in the Treatment of HP-positive Gastric MALT Lymphoma

Inclusion Criteria: * Age ≥ 18 years old * Histologically confirmed gastric mucosa-associated lymphoid tissue (MALT) lymphoma; * Current infection with Helicobacter pylori (Hp): Diagnosis can be made if any of the following criteria are met: a) Positive result in at least one of the following: RUT (rapid urease test), histological staining, or bacterial culture of gastric mucosal tissue; b) Positive result in 13C or 14C-UBT (urea breath test); c) Positive result in HpSA detection. A positive result in serum Hp antibody test indicates past infection, and patients who have never been treated can be considered as having current infection. * ECOG (Eastern Cooperative Oncology Group) performance status 0-2. * Lugano staging I-II1. * Signed informed consent form. * Evaluable lesions present. Exclusion Criteria: * Negative for Helicobacter pylori (HP); * History of other tumors, except for cured cervical cancer or basal cell carcinoma of the skin; * Patients with active HIV and syphilis infections; * Pregnant or lactating women; * Patients with severe active infections; * Patients with multiple factors affecting oral medication (such as dysphagia, nausea, vomiting, chronic diarrhea, and intestinal obstruction); * Other comorbidities or conditions that may prevent patients from completing the clinical trial.