Pharmacist-Driven Stress Ulcer Prophylaxis Minimization in the Intensive Care Unit (NCT06225167) | Clinical Trial Compass
CompletedNot Applicable
Pharmacist-Driven Stress Ulcer Prophylaxis Minimization in the Intensive Care Unit
United States120 participantsStarted 2023-05-13
Plain-language summary
Pharmacologic stress ulcer prophylaxis is routinely used in the intensive care unit (ICU) to prevent upper gastrointestinal (GI) bleeding in critically ill patients.
Who can participate
Age range18 Years – 85 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients ≥18 years ICU location status
Exclusion Criteria:
* If patient has one of the following:
* Coagulopathy (defined as: platelets \< 50,000/µL, international normalized ratio(INR) \> 1.5, or partial thromboplastin time \> 2 times the control value)
* Mechanical ventilation for \> 48 hours and on \< 50% goal tube feeds
* Shock state on vasopressors/inotropes and on \< 50% goal tube feeds (or \< 50% of diet)
* On total parenteral nutrition
* Use of acid suppressive therapy prior to admission
* Admission with GI bleeding
* History of peptic ulcer disease
* Surgery on the GI tract or cardiac surgery during the current hospital admission
* Pregnancy
* H. pylori infection treatment
* Hypersecretory disorder (ex: Zollinger-Ellison)
* Known erosive esophagitis/gastritis (not heartburn or gastroesophageal reflux disease)
* Traumatic brain injury with Glasgow Coma Scale score ≤ 10
* Major burn (˃30% body surface area)
* Major trauma requiring ICU admission
* Spinal cord injury requiring ICU admission
If patient has two or more of the following:
* Administration of ˃ 100 mg daily of prednisolone (or equivalent)
* Sepsis
* Acute renal failure
* Acute hepatic failure