CompletedNot Applicable

Intrarenal Venous Flow Change During Fluid Removal in Critically Ill Patients: A Prospective Exploratory Study

Thailand52 participantsStarted 2024-01-23

Plain-language summary

This clinical trial aims to study intrarenal venous flow patterns change, VExUS score change, and LUS score change during fluid removal treatment in critically ill patients

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Adult patients aged 18 years old or older who will be admitted to the medical intensive care unit
✓. Expected to be hospitalized in the intensive care unit for more than 120 hours.
✓. The patient has stable vital signs without the need for vasoactive medications or rapid fluid resuscitation (at least 500 milliliters of colloid or 1000 milliliters of crystalloid via rapid intravenous infusion) for a minimum consecutive period of 12 hours. This includes cases where the patient receives norepinephrine at a rate not exceeding 0.1 micrograms per kilogram per minute and dobutamine at a rate not exceeding 10 micrograms per kilogram per minute, or when the patient can maintain a continuous reduction in vasoactive medications for a minimum consecutive period of 12 hours.
✓. The patient does not exhibit signs suggestive of inadequate organ perfusion, such as mottling skin, a capillary refill time of more than 2 seconds when nailbeds are pressed and released, or cold extremities.
✓. The patients require fluid removal through decisions made by attending staff or clinical guidelines, which may involve the administration of diuretics or Renal Replacement Therapy.

Exclusion criteria

✕. Underlying chronic kidney disease (eGFR\< 30) before enrollment
✕. Chronic renal replacement therapy (RRT) before enrollment such as on intermittent hemodialysis, peritoneal dialysis
✕. Decompensated cirrhosis with portal hypertension
✕. Inferior vena cava, portal vein, hepatic, renal vein thrombosis
✕. Ureteral obstruction
✕. Intraabdominal hypertension (Intraabdominal pressure \> 12 mmHg)
✕. Previous allergic or anaphylactic to diuretic
✕. Pregnant women

What they're measuring

intrarenal venous flow patterns change during fluid removal treatment in critically ill patients.

Timeframe: 72 hours after Fluid removal therapy

Trial details

NCT IDNCT06216119

SponsorMahidol University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-09-16

View on ClinicalTrials.gov More Critical Illness trials