RecruitingNot Applicable

Genomic Sequencing in Anatomically Normal Fetuses

United States1,000 participantsStarted 2024-01-01

Plain-language summary

This cohort study will examine the clinical utility of genomic sequencing (GS) in patients undergoing prenatal diagnostic procedures (chorionic villus sampling or amniocentesis) for routine indications other than a structural fetal anomaly.

Who can participate

Age range18 Years – 64 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Pregnant patients who are: * Pregnant with a structurally normal fetus (singleton or multiple gestation) * Planning to undergo prenatal diagnosis by either chorionic villus sampling or amniocentesis with chromosome microarray analysis for routine indications * Planning, or have already completed expanded carrier screening Exclusion Criteria: Pregnant patients who: * Decline prenatal diagnostic testing * Are pregnant and their fetus has a known anomaly * Declined chromosomal microarray analysis of expanded carrier screening

What they're measuring

Detection of pathogenic or likely pathogenic variants with genomic sequencing

Timeframe: Up to 2 months after enrollment

Trial details

NCT IDNCT06211348

SponsorUniversity of California, San Francisco

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-01

Contact for this trial

Nuriye Sahin Hodoglugil, DrPH

415-353-3400 Nuriye.Sahin-Hodoglugil@ucsf.edu

View on ClinicalTrials.gov More Pregnant Individuals Requesting Standard Microarray trials