Patients with disorders of gut-brain interaction (DGBI) often present gastrointestinal symptoms that do not show noticeable irregularities in standard examinations. However, due to unclear causes and a high prevalence rate, this condition often exerts a profound impact on the physical and mental health of patients. The scope of DGBI encompasses conditions such as laryngopharyngeal reflux, functional dyspepsia, and irritable bowel syndrome. Previous research has confirmed that in patients with DGBI, their autonomic nervous system exhibits an imbalance, charact erized by decreased parasympathetic activity and dominant sympathetic activity. Diaphragmatic breathing helps reduce the respiratory rate and can stimulate parasympathetic activity while suppressing sympathetic activity. Hence, it is now officially recommended as an effective adjunct therapy for relieving symptoms of gastroesophageal reflux. Accordingly, this study plans to implement a randomized controlled trial, introducing diaphragmatic breathing to patients with DGBI who exhibit normal results in objective examinations. This work allows evaluate changes in their psychophysical symptoms before and after treatment, as well as alterations in the autonomic nervous system .
Age range
18 Years – 70 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Change from Baseline on the Functional Dyspepsia Scale(FD) at 14 days
Timeframe: Baseline and day 14
Change from Baseline on the Irritable Bowel Syndrome Scale(IBS) at 14 days
Timeframe: Baseline and day 14
Change from Baseline on the Gastroesophageal Reflux Disease Questionnaire(GERDQ) at 14 days
Timeframe: Baseline and day 14
Change from Baseline on the Reflux Symptom Index (RSI) at 14 days
Timeframe: Baseline and day 14
Change from Baseline in Pain on the Gastrointestinal symptom rating scale (GSRS) at 14 days
Timeframe: Baseline and day 14
Change from Baseline on the Pittsburgh sleep quality index (PSQI) at 14 days
Timeframe: Baseline and day 14
Change from Baseline on the Taiwanese Depression Scale (TDQ) at 14 days
Timeframe: Baseline and day 14
Change from Baseline on the State-Trait Anxiety Inventory (STAI) at 14 days
Timeframe: Baseline and day 14
Change from Baseline on the Perceived Stress Scale(PSS-10) at 14 days
Timeframe: Baseline and day 14
Change from Baseline on the Esophageal Hypervigilance and Anxiety Scale (EHAS) at 14 days
Timeframe: Baseline and day 14
Change from Baseline on the Laryngeal Hypervigilance and Anxiety Scale (LHAS) at 14 days
Timeframe: Baseline and day 14
Change from Baseline on the Visceral Sensitivity Index (VSI) at 14 days
Timeframe: Baseline and day 14