Comparative Bioavailability of Intranasal Epinephrine

Exclusion criteria

• ✕. Known history or presence of hypersensitivity or idiosyncratic reaction to epinephrine, sulfite, other excipients of epinephrine auto-injector, or any other drug substances with similar activity.
• ✕. Known history or presence of clinically significant lactose, galactose, or fructose allergy
• ✕. Known history or presence of any food allergy.
• ✕. Presence of nostril or septum piercing.
• ✕. Presence of abnormal nasal anatomy (e.g., polyps, unilateral or bilateral abnormalities of the nares, nasal turbinates, or septum including deviated septum).
• ✕. History of nasal surgery.
• ✕. Presence of a medical condition requiring regular medication (prescription and/or over-the-counter) with systemic absorption other than oral contraceptives.
• ✕. History of drug or alcohol addiction requiring treatment or positive alcohol breath test at check-in.