CompletedNot Applicable

Personalized Noninvasive Support in Acute Hypoxemic Respiratory Failure

Italy20 participantsStarted 2024-01-12

Plain-language summary

The optimal noninvasive respiratory support for acute hypoxemic respiratory failure is debated. Recent preliminary data indicate that both pressure-support noninvasive ventilation (NIV) and continuous-positive airway pressure (CPAP) may be of benefit. While often applied interchangeably in clinical practice, NIV and CPAP have different effects on the inspiratory effort, which is the major determinant of self-inflicted lung injury. Also, inspiratory effort widely varies among individuals. The purpose of this study is to assess the physiological effects of a noninvasive respiratory support approach guided by inspiratory effort, as compared to CPAP and NIV, in patients with moderate-to-severe acute hypoxemic respiratory failure.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Acute hypoxemic respiratory failure and PaO2/FiO2\<200 mmHg * PaCO2\<45 mmHg * Respiratory failure not caused by exacerbation of chronic pulmonary disease, cardiac failure or fluid overload Exclusion Criteria: * Pregnancy * Contraindication to helmet support * Contraindication to esophageal manometry * Contraindication to electrical-impedance tomography monitoring * Recent surgery involving the abdomen or the thorax * Pneumothorax or documented barotrauma

What they're measuring

Tidal volume

Timeframe: 1 hour

Transpulmonary driving pressure

Timeframe: 1 hour

Trial details

NCT IDNCT06202144

SponsorFondazione Policlinico Universitario Agostino Gemelli IRCCS

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-06-01

View on ClinicalTrials.gov More Acute Hypoxic Respiratory Failure trials