CompletedNot Applicable

UR+AIMS Gout Wearable Skin Uric Acid Monitor Study

United States6 participantsStarted 2025-03-10

Plain-language summary

15 patients with gout \[10 patients no recent urate-lowering therapy (ULT) and 5 patients on stable urate-lowering therapy (ULT)\] will be invited to participate in a standardized meal at the UCLA Human Nutrition Center and a 7-day community follow-up for the measurement of uric acid (and other metabolites) using our Uric Acid and Metabolite Monitor System (UR+AIMS) skin patch.

Who can participate

Age range18 Years

SexALL

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Inclusion criteria

✓. Age \> 18 with diagnosis of gout (screening positive ACR/EULAR Gout Classification Criteria - see screening survey) and eGFR \> 60 (within the last 12-months).
✓. For the 10 patients with gout off urate-lowering therapy (ULT) \[no Allopurinol, febuxostat, or probenecid prescription within the last 6-months\] and serum urate (SU) \> 7 mg/dL (within the last 12-months).
✓. For the 5 patients with gout on urate-lowering therapy (ULT) \[no dose change within the last 30 days\].

Exclusion criteria

✕. Contraindications to miosis, which include acute iritis, narrow-angle glaucoma
✕. Known Hypersensitivity to pilocarpine hydrochloride
✕. Pupillary block glaucoma (ophthalmic solution)
✕. Subjects reporting any allergy to glue or latex or any allergy to food that will be provided in the study (sardines in extra virgin olive oil and Sprite).

What they're measuring

Evaluate tolerability and adherence of daily recorded patch wear time.

Timeframe: 3 years

Recording of uric acid (and oxypurinol) measurements while wearing patch.

Timeframe: 3 years

Trial details

NCT IDNCT06187519

SponsorUniversity of California, Los Angeles

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-06-18

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