Exercise Testing Protocols for Females and Males With CAD (NCT06179212) | Clinical Trial Compass
RecruitingNot Applicable
Exercise Testing Protocols for Females and Males With CAD
Canada54 participantsStarted 2024-03-01
Plain-language summary
The aim of this study is to determine if the test that allows males to achieve a higher VO2 (a measure of oxygen use during exercise) is different for females. The purpose of this study is to test 4 different exercise testing protocols to compare measured oxygen consumption in females and males with CAD (disease caused by the buildup of plaque in the artery walls which can lead to insufficient amounts of blood, nutrients and oxygen being supplied to the heart). The 4 exercise tests that will be completed on the treadmill are the modified Balke, modified Bruce, modified Naughton and University of Ottawa Heart Institute Slow Ramp protocols. Each test has a different stage duration (the amount of time that the test remains at a pre-determined speed and incline), and incremental increase in speed and incline.
The main purpose of this study is to compare VO2 peak (the maximal amount of oxygen utilized during the exercise test) of females and males with CAD in 4 different exercise protocols. For example, the investigators will find out:
1. which exercise protocol is more likely to achieve a higher peak V̇O2 in females and which protocol is more likely to achieve a higher peak V̇O2 in males,
2. if enjoyment affects the duration of the test, and
3. how different exercise test protocols will provide different results of maximal oxygen used by the participant's body during the exercise test.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. 18 years and older;
✓. previous CAD diagnosis by a physician;
✓. can perform a CPET until volitional exhaustion;
✓. are able to self-ambulate on a treadmill;
✓. are at least 8 weeks post cardiovascular event or procedure (i.e., percutaneous coronary intervention (PCI), coronary artery bypass graft (CABG)); and,
✓. are able to provide written informed consent.
Exclusion criteria
✕. cannot speak, read, write, or understand English or French;
✕. currently not enrolled in a CR program;
✕. have recently changed (or planning to change) PA levels within the previous 4 weeks (as this may impact the ability to compare outcomes between exercise testing protocols);
✕. have heart failure with an ejection fraction \<45% (indication of possible cardiomyopathy);6
What they're measuring
1
Oxygen Consumption (VO2)
Timeframe: Week 1 to week 4 (measured weekly, at every appointment)
Trial details
NCT IDNCT06179212
SponsorOttawa Heart Institute Research Corporation