The purpose of this study is to evaluate the safety, tolerability, and immunogenicity of V116 compared to PPSV23 in children and teenagers 2 through 17 years of age, who had completed routine pneumococcal vaccine as infants/toddlers. Researchers want to learn if V116 is as good as, or is better than the PPSV23 vaccine in terms of the antibody immune response. V116 and PPSV23 will be studied in children and teenagers who have a higher risk of getting pneumococcal disease (PD).
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Percentage of Participants With Solicited Injection-site Adverse Events (AEs)
Timeframe: Up to 5 days postvaccination
Percentage of Participants With Solicited Systemic AEs
Timeframe: Up to 5 days post vaccination
Percentage of Participants With Vaccine-related Serious Adverse Events (SAEs)
Timeframe: Up to approximately 6 months
Geometric Mean Titer of Serotype-specific Opsonophagocytic Activity (OPA) Responses
Timeframe: 30 days postvaccination