Ventilator Trigger Sensitivity Adjustment Versus Threshold Inspiratory Muscle Training on Arteria… (NCT06167239) | Clinical Trial Compass
RecruitingNot Applicable
Ventilator Trigger Sensitivity Adjustment Versus Threshold Inspiratory Muscle Training on Arterial Blood Gases
Egypt45 participantsStarted 2023-05-02
Plain-language summary
The aim of the current study is to compare the effect of ventilator trigger sensitivity adjustment versus threshold inspiratory muscle training on arterial blood gases in mechanically ventilated patients.
Who can participate
Age range
20 Years – 55 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
. Difficult to wean Guillain barre patients who have been on MV for at least 48 hours. Difficult to wean subjects have been defined as those who fail the first spontaneous breathing trial (SBT)and may require up to 3 SBTs or up to 7 d from the first attempt to achieve successful weaning (B´eduneau G. et al.,2017) and (Annia F. et al.,2019).
. Age: \>18 years.
. Both sexes will be included.
. Ventilator mode: Pressure support mode with FiO2≤ 0.5, positive end expiratory pressure (PEEP) will be\<8-10cm/H2Oand respiratory rate \< 25.
. Conscious oriented patient with Glasgow coma score ≥13.
. Alertness will be titrated to a Riker Sedation Agitation Score of 4.
. PH\>7.25, arterial oxygen saturation \>90%.
. Cardiovascular stability.
Exclusion criteria
. Persistent hemodynamic instability as life threatening arrhythmias, acute heart failure.
. Severe breathlessness, when spontaneously breathing.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
PH
Timeframe: Pre intervention and immediate post intervention, through study completion, an average of two weeks
2
PaO2
Timeframe: Pre intervention and immediate post intervention, through study completion, an average of two weeks
3
PaCO2
Timeframe: Pre intervention and immediate post intervention, through study completion, an average of two weeks
4
HCO3
Timeframe: Pre intervention and immediate post intervention, through study completion, an average of two weeks