RecruitingPhase 4

Liposomal and Standard Bupivacaine in Thoracic Paravertebral Block for Post-Thoracoscopic Pain

China496 participantsStarted 2024-06-01

Plain-language summary

I. Research purpose 1.1 Main Objective: To investigate the efficacy and safety of bupivacaine liposome thoracic paravertebral nerve block for postoperative analgesia after thoracoscopic lobectomy 1.2 Exploratory Objective: To investigate the noninferiority of bupivacaine liposomes in thoracic paravertebral nerve block with standard bupivacaine

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 1\) Age ≥18 years old; 2\) Patients undergoing unilateral initial thoracoscopic lobectomy under general anesthesia (TV or robot-assisted); 3\) American Society of Anesthesiologists (ASA) Grade I - III; 4\) Voluntarily participate in the study and sign the informed consent. Exclusion Criteria: * 1\) Pregnant or lactating women; 2\) Pulmonary wedge-shaped resection; 3\) ≥2 thoracic drainage tubes; 4\) Abnormal liver function: ALT and/or AST\>2×ULN, or TBIL≥1.5×ULN; 5\) Renal function impairment (serum creatinine \>176μmol/L), or received dialysis treatment within 28 days before surgery; 6\) Participate in another research trial involving an investigational drug within 6 months; 7\) A history of drug or alcohol abuse; 8\) Long-term use of opioids (more than 3 months or more than 5 mg daily morphine equivalent per day for 1 month); 9\) History of allergy to local anesthetics or one of the investigational drugs; 10\) Uncontrolled mental or neurological symptoms.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

area under the NRS score curve (AUC) for resting

Timeframe: 48hours postoperative

Trial details

NCT IDNCT06165991

SponsorYongtao Sun

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-01-30

Contact for this trial

yong t Sun, PH.D

18660795201 sunyongtao1979@163.com

View on ClinicalTrials.gov More Thoracic Paravertebral Block trials