Malaria Burden in Pregnant Women and the Incidence of Pregnancy in a Cohort of Nulligravida

Inclusion Criteria: * For subgroup 1 * Nulligravidae aged ≥ 15 years * Residing within the study area and planning to stay for the study duration * Signed or thumb-printed informed consent obtained from participant/participant legally acceptable representatives. An assent will be obtained from minors. * For subgroups 2 and 3 * Primigravidae aged ≥ 15 years at the time of enrolment * Residing within the study area for the last three months * Signed or thumb-printed informed consent obtained from participant/participant legally acceptable representatives. An assent will be obtained from minors. * Additional criteria for subgroup 3 • Third trimester of gestational age Exclusion Criteria: * For subgroup 1 only * Women of non-childbearing potential. Non-childbearing potential is defined as current bilateral tubal ligation or occlusion, hysterectomy, bilateral ovariectomy or post-menopause. * Women reporting established use of oral, injected or implanted hormonal contraceptives; intrauterine device or intrauterine system * For all the subgroups * Chronic use of i) immunosuppressive drugs, ii) or other immune modifying drugs within three months prior to enrolment in the study * Known history of Human Immunodeficiency Virus (HIV) (No test will be done by the study) * Use of any other investigational or non-registered product (drug or vaccine) during the study period. * Any previous participation in any malaria (vaccine) study. * Any other condition or…