Ulcer Location and Debridement Frequency: Weekly vs. Biweekly Sharp Debridement in Diabetic Foot Ulcers

Inclusion Criteria: * Men and women aged 18 years or older who provide written informed consent. * Patients with Type 1 or Type 2 Diabetes mellitus with a glycated hemoglobin (HbA1c) concentration ≤ 10% (determined in the past 3 months). * DFUs with the following locations: digital, under metatarsal head, midfoot, and hindfoot. * DFUs of grades IA, IIA, IB, IIB, IC, IIC, ID, and IID according to the University of Texas Classification. * DFUs with grades PEDIS 1 - no infection, PEDIS 2 - mild infection, and PEDIS 3 - moderate infection, as per the PEDIS-IDSA classification. * Neuropathic and neuroischemic ulcers. * DFUs with grades 0 (absence of ischemia), 1 (mild ischemia), and 2 (moderate ischemia) according to the WIfI (Wound, Ischemia, and foot Infection) Classification, determined by palpation of at least one distal pulse, Ankle-brachial index (ABI) ≥ 0.5, ankle systolic blood pressure ≥ 50 mmHg, or a value ≥ 30 mmHg for toe systolic blood pressure and transcutaneous oxygen pressure (TcpO2). * Study ulcer surface area between 0.5 cm² and 30 cm² after debridement. * Duration of the DFU between 2-50 weeks Exclusion Criteria: * Patients with severe renal insufficiency requiring dialysis. * Patients with congestive heart failure (CHF) above Class II, meaning CHF that causes a limitation of physical activity. * Patients with active coronary disease or a significant adverse cardiac event in the past 18 months, defined as any of the following circumstances: fluctuating sympto…