Regenerative Treatment of Peri-implantitis

Inclusion Criteria: * Age ≥ 18 years * Physical status according to the American Society of Anesthesiology (ASA) I or II, which include patients who are systematically healthy or may suffer from mild to moderate, however well-controlled systemic diseases. * Subjects having at least one dental implant with peri-implantitis according to the definition proposed by the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions (Berglundh et al., 2018): * Full-mouth plaque score and full-mouth bleeding score ≤ 20% (measured at four sites per tooth) * Correct 3-dimensional implant positioning, or buccal position ≤ 1 mm * Implants which have been in function for at least 6 months Exclusion Criteria: * A clearly mal-positioned dental implant * Significant interproximal horizontal bone loss (more than 50% of implant fixture length) * A mobile dental implant * Presence of uncontrolled or untreated periodontal disease * More than 2 weeks usage of antibiotics in the past two months * Subjects taking medications known to modify bone metabolism or those that can interfere with the normal wound healing (such as bisphosphonates, corticosteroids, hormone replacement therapy, parathyroid hormone, denosumab, strontium ranelate, etc.), or those with uncontrolled systemic diseases or conditions that may similarly affect the patient's healing (osteoporosis, osteopenia, hyperparathyroidism, Paget's disease, uncontrolled diabetes (HBA1c \> 8)). * Pregnant su…