Out of all proportion to its short duration, the perioperative period is critical in determining the long-term outcome of cancer. To contribute to a better understanding of the neural and inflammatory mechanisms underlying this issue, we aim to implement a novel intervention based on the preoperative use of non-steroidal anti-inflammatory drugs (NSAIDs) with or without an anti-epileptic drug. Our goal is to understand and transform the perioperative window from being a facilitator of metastatic progression to arresting and/or eliminating residual disease using repurposing drugs
Age range
18 Years – 70 Years
Sex
FEMALE
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
To detect a reduced increase in systemic inflammation (from baseline to up to 24 hours after surgery) using peri-operative ketorolac
Timeframe: Up to 24 hours after surgery
To detect a reduced increase in systemic neurotransmitters (from baseline to up to 24 hours after surgery) using peri-operative pregabalin
Timeframe: Up to 24 hours after surgery
Change in biomarkers of metastasis at surgery from baseline
Timeframe: At surgery
Change in tumoral immune cells recruitment at surgery from baseline
Timeframe: At surgery
Change in tumoral neurogenesis at surgery from baseline
Timeframe: At surgery
Change in tumoral neurotransmitters level at surgery from baseline
Timeframe: At surgery
Change in Peripheral Blood Mononuclear Cells at surgery from baseline
Timeframe: At surgery
Change in systemic neuro-inflammatory mediators at surgery from baseline
Timeframe: At surgery
Change in systemic neurotransmitters at surgery from baseline
Timeframe: At surgery